I was listening to a webinar last night by Dr. William Shaw of Great Plains Labs. They do a lot of lab testing for Autsim and other related diseases, and spme non related disease. I send a lot of Jesse's labs there for work up. Last night he did a webinar on Tylenol. Here's some thing I have noted from. Bottom, not a good choice of fever and pain reliever.
Dr Shaw seems to be leaning towards it being a major contributing factor of Autism, so what's it doing for kids like ours who already a missing enzyme to break down garbage?
He started out talking about a comparison that was done looking at autism rates in Cuba vs the US. We have a roughly 300% higher autism rate than they do. So he started looking at what things might be different, such as the numbers of vaccines given. Turns out the vaccine rates are about the same. Whats different is that acetominophen isn't available OTC in Cuba, the amount given by RX is strictly controlled (something like 20 tablets max) and it typically isn't used to treat fevers.
So they looked at autism rates to see if there was any correlation between increased use of acetominophen, i.e after aspirin was associated with Reyes Syndrome and there seemed to be a trend. Autism numbers dropped after the Tylenol scares and increased once Tylenol usage increased.
Then he talked about the different pathways the body has to excrete the stuff, ie PST, Glucuronic acid, a cannabinoid pathway, and cytochrome P450 enzyme system (not the pathway you want). The P450 enzyme system converts Tylenol into something called NAPQI (N-acetyl-p-benzo-quinone imine), a nasty compound that gets detoxified by glutathione.
So he explains the glutathione cycle, how its recycled, and how the body produces just whats needed. NAPQI depletes glutathione and inhibits the enzymes that allow the recycling to take place. So if for some reason your body cant use the optimal pathways (sulfation, glucoronidation or the cannabinoid path which isnt so optimal) then your stuck with NAPQI which is toxic to the liver. (Our kids have sulfation issues anyway one metabolic geneticist told me, they need more of it)
So he goes on to explain when youre sick, glutathione levels are likely low and then you treat with Tylenol and its a double whammy to your system. He talked about how NAPQI can cross the placental barrier, so taking the stuff while pregnant is likely just as bad as giving it to a kid in conjunction with vaccines. He also talked about its association with mito disfunction, asthma, allergies. He explains that Too much acetaminophen will cause acidosis. It exasperates asthma. (There is a strong link between pregnant moms taking tylenol and young babies develop wheezing and asthma). Even at indicated doses, it inhibits the division of monocytes.
He also discussed how the byproducts of acetaminophen (when not properly excreted) can lead to malfunction in synthesis of many proteins and creation of neurotransmitters as well as affecting binding sites of neurotransmitters and cannabinoid receptors. There was also a connection drawn to significantly less dendritic branching in the brain (another issue with our kids bain) and areas of the brain like the corpus callosum (and two others which I can't recall the names of) that appeared to be affected by an adverse reaction to the acetaminophen.
There is also some question about the strength and purity of many children's pain reliever's that were manufactured by Johnson and Johnson in some specific plants. Problems have been documented back as far as 2003, but may reach further back in time.
GPL is suppose to start a Facebook page about this. Just an FYI for everyone as many issues in Autism can be issues for our kids too.
They are going to launch three studies and are looking for participants. You can check it out here: